Research News | ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute /umbi Leading Institute in Molecular Medicine Mon, 18 May 2026 01:55:56 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 UMBI Research Spotlight No.2/2026 /umbi/news/umbi-research-spotlight-no-2-2026/ Mon, 18 May 2026 01:54:01 +0000 /umbi/?post_type=news&p=104477 ð„ð±ð©ð¥ð¨ð«ð¢ð§ð  ð‚ð¡ðšð¥ð¥ðžð§ð ðžð¬ ðšð§ð ðˆð§ð­ðžð ð«ðšð­ð¢ð¯ðž ð’ð¨ð¥ð®ð­ð¢ð¨ð§ð¬ ð¢ð§ ð’ð¢ð§ð ð¥ðž-ð‚ðžð¥ð¥ ðˆð¦ð¦ð®ð§ð¨ð¥ð¨ð ð² UMBI is pleased to share a recent review article by our researchers, led by Dr. Nor Adzimah ...

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ð„ð±ð©ð¥ð¨ð«ð¢ð§ð  ð‚ð¡ðšð¥ð¥ðžð§ð ðžð¬ ðšð§ð ðˆð§ð­ðžð ð«ðšð­ð¢ð¯ðž ð’ð¨ð¥ð®ð­ð¢ð¨ð§ð¬ ð¢ð§ ð’ð¢ð§ð ð¥ðž-ð‚ðžð¥ð¥ ðˆð¦ð¦ð®ð§ð¨ð¥ð¨ð ð²

UMBI is pleased to share a recent review article by our researchers, led by Dr. Nor Adzimah Johdi, published in ð‘°ð’Žð’Žð’–ð’ð’ð’ð’ð’ˆð’Šð’„ ð‘¹ð’†ð’”ð’†ð’‚ð’“ð’„ð’‰, examining current challenges and emerging approaches in immune cell annotation within single-cell studies.

ð’ð¢ð§ð ð¥ðž-ðœðžð¥ð¥ ð‘ðð€ ð¬ðžðªð®ðžð§ðœð¢ð§ð  (ð¬ðœð‘ðð€-ð¬ðžðª) has significantly advanced immunology research by enabling high-resolution profiling of individual immune cells. However, accurately identifying immune cell populations remains complex, particularly when transcriptomic signals do not always correspond directly with protein expression. This review discusses how these biological and technical challenges can influence ððšð­ðš ð¢ð§ð­ðžð«ð©ð«ðžð­ðšð­ð¢ð¨ð§ in areas such as cancer, infectious diseases, and autoimmune disorders.

The article provides an ð¨ð¯ðžð«ð¯ð¢ðžð° ð¨ðŸ ðžð¦ðžð«ð ð¢ð§ð  ð¦ð®ð¥ð­ð¢ð¦ð¨ððšð¥ ð­ðžðœð¡ð§ð¨ð¥ð¨ð ð¢ðžð¬, including CITE-seq and spatial transcriptomics, which combine transcriptomic, proteomic, and spatial information to support more reliable immune cell characterization. It also highlights ð«ðžðœðžð§ð­ ððžð¯ðžð¥ð¨ð©ð¦ðžð§ð­ð¬ ð¢ð§ ðœð¨ð¦ð©ð®ð­ðšð­ð¢ð¨ð§ðšð¥ ðšð§ð ð›ð¢ð¨ð¢ð§ðŸð¨ð«ð¦ðšð­ð¢ðœð¬ ðŸð«ðšð¦ðžð°ð¨ð«ð¤ð¬ designed to improve the integration and interpretation of multi-omics datasets.

Why these matters?

Improving the accuracy of immune cell annotation is increasingly important for advancing precision medicine and translational research. More robust analytical approaches may contribute to better understanding of disease mechanisms, improved therapeutic stratification, and the identification of potential treatment targets.

This publication also reflects UMBI’s continued efforts to contribute to the broader scientific community through interdisciplinary research spanning immunology, genomics, and computational biology.

We invite colleagues and collaborators to explore the full review:

George, S., Johdi, N.A. Immune cell annotation in the single-cell studies: technologies, challenges, and integrative solutions. ð‘°ð’Žð’Žð’–ð’ð’ð’ ð‘¹ð’†ð’” ðŸ•ðŸ’, 46 (2026)

As single-cell and multi-omics technologies continue to evolve, integrative approaches such as these may help strengthen future research in immunology and precision health.

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#Research #SingleCell #Immunology #Multiomics #PrecisionMedicine #BiomedicalResearch #Bioinformatics #UMBI #¼¯ÃÀÂ鶹 #Innovation

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SDG 3 | SDG 4 – Health/Wellbeing, Education, Quality of life

The post UMBI Research Spotlight No.2/2026 first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> UMBI Research Spotlight No.1/2026 /umbi/news/umbi_research_spotlight_no1_2026/ Mon, 11 May 2026 05:58:43 +0000 /umbi/?post_type=news&p=104456 ð„ð©ðÔÃð€ðŒ: ð“ð¡ðÃÆ ð†ðÃÆð§ðÃÆð­ð¢ðœ ð„ð§ð ð¢ð§ðÃÆ ðƒð«ð¢ð¯ð¢ð§ð  ð„ð¬ð¨ð©ð¡ðšð ðÃÆðšð¥ ðÔÃðšð§ðœðÃÆð« ð€ð ð ð«ðÃÆð¬ð¢ð¨ð§ UMBI is pleased to share a peer-reviewed publication led by Ts. Dr. Mohamad Aimanuddin Mohtar in PeerJ. ...

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ð„ð©ðÔÃð€ðŒ: ð“ð¡ðÃÆ ð†ðÃÆð§ðÃÆð­ð¢ðœ ð„ð§ð ð¢ð§ðÃÆ ðƒð«ð¢ð¯ð¢ð§ð  ð„ð¬ð¨ð©ð¡ðšð ðÃÆðšð¥ ðÔÃðšð§ðœðÃÆð« ð€ð ð ð«ðÃÆð¬ð¢ð¨ð§

UMBI is pleased to share a peer-reviewed publication led by Ts. Dr. Mohamad Aimanuddin Mohtar in PeerJ. The team explored the potential role of EpCAM in the development and progression of esophageal adenocarcinoma (ESCA).

Key highlights from the study include:

  • ð’ð­ð®ðð² ð…ð¨ðœð®ð¬

Researchers investigated the role of the Epithelial cell adhesion molecule (EpCAM) in esophageal adenocarcinoma by using a unique EpCAM-null cell line (FLO-1) to observe the direct effects of the protein without background interference.

  • ð„ð§ð¡ðšð§ðœðÃÆð ð€ð ð ð«ðÃÆð¬ð¬ð¢ð¯ðÃÆð§ðÃÆð¬ð¬

The reintroduction of EpCAM into these cells significantly increased their pro-tumorigenic behaviors, including enhanced cell migration, adhesion, invasive capacity, and overall survival.

  • ð“ð«ðšð§ð¬ðœð«ð¢ð©ð­ð¨ð¦ð¢ðœ ð‘ðÃÆð©ð«ð¨ð ð«ðšð¦ð¦ð¢ð§ð 

RNA sequencing revealed that EpCAM acts as a major genetic regulator, significantly altering the expression of 797 genes primarily linked to cell motility, adhesion, and transmembrane activity.

  • ðŒð¢ðœð«ð¨ðÃÆð§ð¯ð¢ð«ð¨ð§ð¦ðÃÆð§ð­ ð‘ðÃÆð¦ð¨ððÃÆð¥ð¢ð§ð 

The study identified specific “hub genes,” notably COL1A1 and PXDN, which are upregulated by EpCAM to remodel the extracellular matrix (ECM), effectively creating a supportive environment for the cancer to spread.

  • ðÔÃð¥ð¢ð§ð¢ðœðšð¥ ðˆð¦ð©ð¥ð¢ðœðšð­ð¢ð¨ð§ð¬

By mapping this EpCAM signaling axis, the research positions EpCAM and its downstream ECM-remodeling effectors as critical therapeutic vulnerabilities and promising biomarkers for future targeted ESCA treatments.

At UMBI, we continue to support research efforts that contribute to a deeper understanding of cancer biology and its translation into meaningful clinical insights.

We invite colleagues and collaborators to explore the full study:

Mohtar MA et al., PeerJ (2026)

We hope this work contributes to ongoing efforts in understanding esophageal cancer and supports future studies aimed at improving patient outcomes.

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#Research #CancerBiology #CancerGenomics #TranslationalResearch #PrecisionMedicine #UMBI #¼¯ÃÀÂ鶹 #BiomedicalScience

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SDG 3 | SDG 4 – Health/Wellbeing, Education, Quality of life

The post UMBI Research Spotlight No.1/2026 first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> 25 April 2025 – World DNA Day /umbi/news/25-april-2025-world-dna-day/ Fri, 24 Apr 2026 08:54:36 +0000 /umbi/?post_type=news&p=104428 By: Dr. Lee Pey Yee & Ahmad Termidzi Mohd Azhar 💡 Have you ever wondered what makes you unique? The answer lies in your DNA—the ...

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By: Dr. Lee Pey Yee & Ahmad Termidzi Mohd Azhar

💡 Have you ever wondered what makes you unique? The answer lies in your DNA—the extraordinary blueprint made up of three billion letters that define how you grow, how you look, and how your body works.

DNA Day commemorates two landmark scientific achievements: the ðð¢ð¬ðœð¨ð¯ðžð«ð² ð¨ðŸ ð­ð¡ðž ðƒðð€ ðð¨ð®ð›ð¥ðž ð¡ðžð¥ð¢ð± ð¬ð­ð«ð®ðœð­ð®ð«ðž ð›ð² ð‰ðšð¦ðžð¬ ð–ðšð­ð¬ð¨ð§ ðšð§ð ð…ð«ðšð§ðœð¢ð¬ ð‚ð«ð¢ðœð¤ ð¢ð§ ðŸðŸ—ðŸ“ðŸ‘, and the completion of the ð‡ð®ð¦ðšð§ ð†ðžð§ð¨ð¦ðž ðð«ð¨ð£ðžðœð­ ð¢ð§ ðŸðŸŽðŸŽðŸ‘. These breakthroughs have revolutionised our understanding of genes and opened new frontiers in biomedical research. The interesting part is that ð¡ð®ð¦ðšð§ð¬ ð¬ð¡ðšð«ðž ð¦ð¨ð«ðž ð­ð¡ðšð§ ðŸ—ðŸ—% ð¨ðŸ ð­ð¡ðžð¢ð« ðƒðð€, yet these minor variations within our genetic code that make each of us unique, be it in the way we look, or how we respond to the world around us.

Today, DNA plays a crucial role in modern medicine. It helps doctors make more precise decisions, enables scientists to better understand diseases, and allows individuals to explore their ancestry. Though small in size, this molecule has a profound impact on our lives.

ð‘ðÃÆð¬ðÃÆðšð«ðœð¡ ð‡ð¢ð ð¡ð¥ð¢ð ð¡ð­ð¬ ðŸð«ð¨ð¦ ð”ðŒððˆ

UMBI continues to lead high-impact DNA research, translating genomic discoveries into practical healthcare solutions aligned with precision medicine and national priorities.

🔬 ðÔÃðšð§ðœðÃÆð« ð†ðžð§ð¨ð¦ð¢ðœð¬

  • UMBI leverages next-generation sequencing (NGS) and advanced bioinformatics to identify genetic drivers of cancer and treatment response. Current focus areas include biomarker discovery and druggable mutations to enable early detection and targeted therapies.

🔬 ðð¨ð§-ð‚ð¨ð¦ð¦ð®ð§ð¢ðœðšð›ð¥ðž ðƒð¢ð¬ðžðšð¬ðžð¬ (ðð‚ðƒð¬)

  • Through genome-wide association studies (GWAS) and epigenetic profiling, UMBI investigates genetic and environmental factors underlying chronic diseases such as cardiovascular disease and diabetes, with emphasis on population-specific risks.

🔬 ðŒð¢ðœð«ð¨ð›ð¢ð¨ð¦ðž ð‘ðÃÆð¬ðÃÆðšð«ðœð¡

  • Research on the human microbiome is uncovering how microbial communities influence diseases, including cancer and metabolic conditions. These insights are driving the development of microbiome-based biomarkers and preventive strategies.

🔬 ðð¨ð©ð®ð¥ðšð­ð¢ð¨ð§-ððšð¬ðžð ð‘ðÃÆð¬ðÃÆðšð«ðœð¡

  • The Malaysian Cohort Project is a large-scale population study involving over 100,000 participants, contributing to the development of a national-scale biobank and big data resource. This initiative integrates genomic, lifestyle, and environmental data to better understand disease patterns among Malaysians. Insights from this cohort support risk prediction, early detection, and the advancement of precision public health strategies tailored to Malaysia’s diverse population. [More on The Malaysian Cohort Project]

🔬 ð“ð¡ðÃÆ ðŒðšð¥ðšð²ð¬ð¢ðšð§ ððšð§ð ðžð§ð¨ð¦ðž

  • Building on whole-genome sequencing of 4,000 individuals from 56 Malaysian sub-ethnic groups, UMBI has developed and launched the Malaysian Pangenome to better capture the country’s genetic diversity. This initiative aims to improve the accuracy of genetic studies, enhance disease risk prediction, and ensure that precision medicine approaches are more inclusive and relevant to local populations.

This DNA Day, take a moment to appreciate the science within you—simple, powerful, and uniquely yours.

Happy DNA Day!

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SDG 3 | SDG 4 | SDG 8 | SDG 16 | SDG 17 – Health/Wellbeing, Education, Quality of life, Global partnership.

The post 25 April 2025 – World DNA Day first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> 3 March 2026 – Triple Negative Breast Cancer Day /umbi/news/triple_negative_breast_cancer_day_2026/ Tue, 03 Mar 2026 00:00:49 +0000 /umbi/?post_type=news&p=104449 By: Dr. Ezanee Azlina binti Mohamad Hanif Triple-negative breast cancer (TNBC) is a complex and highly heterogenous, made up of several intrinsic molecular subtypes that ...

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By: Dr. Ezanee Azlina binti Mohamad Hanif

Triple-negative breast cancer (TNBC) is a complex and highly heterogenous, made up of several intrinsic molecular subtypes that behave differently in patients.

One important group is the immunomodulatory subtype, which shows high immune cell infiltration, active immune gene expression, and engagement of immune checkpoints, reflecting a dynamic interaction between tumour cells and the immune system.

This immune landscape is closely linked with key oncogenic pathways, including BRCA-related DNA repair, PI3K–AKT, TP53, and MAPK signalling, which together influence tumour growth, immune escape, and treatment resistance. These interactions highlight the potential role of immunotherapy, particularly immune checkpoint inhibitors, in selected TNBC patients.

However, in real-world clinical settings such as Malaysia, the high cost of immunotherapy limits its broad application. As such, careful biomarker-based patient selection is essential to maximize clinical benefit, improve cost-effectiveness, and support more equitable access to personalized treatment options.

💗 On #TNBCDay, UMBI reaffirm our commitment to advancing research that supports smarter, more personalised cancer care.

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SDG 3 | SDG 4 | SDG 8 | SDG 16 | SDG 17 – Health/Wellbeing, Education, Quality of life, Global partnership.

The post 3 March 2026 – Triple Negative Breast Cancer Day first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> 4 February 2026 – World Cancer Day /umbi/news/2026_world_cancer_day/ Wed, 04 Feb 2026 00:00:53 +0000 /umbi/?post_type=news&p=104445   💠ð…ðžð›ð«ð®ðšð«ð² ðŸðŸŽðŸðŸ” | ð–ð¨ð«ð¥ð ðÔÃðšð§ðœðÃÆð« ðƒðšð² ðŸðŸŽðŸðŸ” On this World Cancer Day, UMBI reaffirms its commitment to ðšðð¯ðšð§ðœð¢ð§ð  ðœðšð§ðœðžð« ð«ðžð¬ðžðšð«ðœð¡ ð­ð¡ð«ð¨ð®ð ð¡ ð©ð«ðžðœð¢ð¬ð¢ð¨ð§ ð¦ðžðð¢ðœð¢ð§ðž, ...

The post 4 February 2026 – World Cancer Day first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]>  

💠ð…ðžð›ð«ð®ðšð«ð² ðŸðŸŽðŸðŸ” | ð–ð¨ð«ð¥ð ðÔÃðšð§ðœðÃÆð« ðƒðšð² ðŸðŸŽðŸðŸ”

On this World Cancer Day, UMBI reaffirms its commitment to ðšðð¯ðšð§ðœð¢ð§ð  ðœðšð§ðœðžð« ð«ðžð¬ðžðšð«ðœð¡ ð­ð¡ð«ð¨ð®ð ð¡ ð©ð«ðžðœð¢ð¬ð¢ð¨ð§ ð¦ðžðð¢ðœð¢ð§ðž, ensuring every patient receives care that is as unique as their cancer. United by science and driven by impact, UMBI continues to ð­ð«ðšð§ð¬ð¥ðšð­ðž ð¦ð¨ð¥ðžðœð®ð¥ðšð« ðð¢ð¬ðœð¨ð¯ðžð«ð¢ðžð¬ ð¢ð§ð­ð¨ ð›ðžð­ð­ðžð« ð¨ð®ð­ðœð¨ð¦ðžð¬, improved quality of life, and hope for patients and families.

ð”ð§ð¢ð­ðžð ð›ð² ð”ð§ð¢ðªð®ðž

.

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SDG 3 | SDG 4 | SDG 8 | SDG 16 | SDG 17 – Health/Wellbeing, Education, Quality of life, Global partnership.

The post 4 February 2026 – World Cancer Day first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> Ucapan Tahniah Pembentangan Akhir PhD /umbi/news/ucapan-tahniah-pembentangan-akhir-phd/ Fri, 19 Dec 2025 07:17:08 +0000 /umbi/?post_type=news&p=103929 19 December 2025 | Congratulations to Ms. Nur Fadhlina Mohamad Pakarulrazy and Ms. Nursyazwani Omar, two outstanding UMBI PhD candidates, on their exemplary final presentation ...

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19 December 2025 | Congratulations to Ms. Nur Fadhlina Mohamad Pakarulrazy and Ms. Nursyazwani Omar, two outstanding UMBI PhD candidates, on their exemplary final presentation in UMBI Research Update Series in Molecular Medicine (RUS) No. 37/2025.

Ms. Fadhlina shared insight on the intriguing subject of ‘Discovering the Role of ATP-Binding Cassette (ABC) Transporters in Iodide Uptake and Cell Proliferation in Lymph Node Positive and Radioactive Iodine-Refractive Papillary Thyroid Carcinoma’, while Ms. Nursyazwani presented a compelling topic on ‘Elucidating the Proteogenomic Signatures of cryptogenic Hepatocellular Carcinoma (cHCC)’.

Their presentations were thoughtfully summarized by their esteemed supervisor, AP Dr. Nurul Syakima Ab Mutalib and AP Dr. Nadiah Abu respectively.

The presence of industry representatives, Professor Dr. Leong Chee Onn (AGTC Genomics Sdn. Bhd.), Dr. Rose Iszati (Neoscience Sdn. Bhd.) and Dr. Noraini Nordin (Hematogenix Sdn. Bhd.) further highlighted the practical applications and industry relevance of the research by Ms. Fadhlina and Ms. Nursyazwani.

As they progress to the thesis writing and viva presentation phase, we extend our heartfelt best wishes to Ms. Fadhlina and Ms. Nursyazwani for a successful journey ahead. May they continue to exemplify excellence and complete their studies with flying colors.

Congratulations!!

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SDG 4 | Quality Education

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The post Ucapan Tahniah Pembentangan Akhir PhD first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> UMBI Researchers Secure LRGS Grant /umbi/news/umbi-researchers-secure-lrgs-grant/ Thu, 13 Nov 2025 08:00:05 +0000 /umbi/?post_type=news&p=103608 Ìý Congratulations to Associate Professor Dr. Nadiah Abu and her research team on successfully securing the Long-Term Research Grant Scheme (LRGS)! UMBI is proud of ...

The post UMBI Researchers Secure LRGS Grant first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> Ìý

Congratulations to Associate Professor Dr. Nadiah Abu and her research team on successfully securing the Long-Term Research Grant Scheme (LRGS)! UMBI is proud of this remarkable achievement, which reflects the team’s dedication, excellence, and commitment to advancing impactful biomedical research. Well done and may this success continue to inspire future innovations!

 

1) SALVAGE: A Sustainable Platform Using Algal-Derived Lipid Vesicles for Advanced Health Solutions (RM 1,200,000.00)

  • Research Team: Assoc. Prof Dr. Shaza Eva Mohamad (UTM) and Assoc. Prof. Dr. Khuriah Abdul Hamid (UiTM)

2) Mechanistic and Toxicological Evaluation of EV Uptake in Mammalian Cells (RM 378,700.00)

  • Research Team: Prof. Dr. Mohd Cairul Iqbal Mohd Amin (Fac. of Pharmacy, ¼¯ÃÀÂ鶹), Assoc. Prof. Dr. Razinah binti Sharif @ Mohd Sharif (H-Care, ¼¯ÃÀÂ鶹), Ts. Dr. Saiful Effendi Syafruddin (UMBI, ¼¯ÃÀÂ鶹) and Dr. Lee Pey Yee (UMBI, ¼¯ÃÀÂ鶹)
The post UMBI Researchers Secure LRGS Grant first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> UMBI’s Researcher at the 3rd Youth Forum on Agricultural Biotechnology held in Dhaka, Bangladesh /umbi/news/umbis-researcher-at-the-3rd-youth-forum-on-agricultural-biotechnology-held-in-dhaka-bangladesh/ Wed, 17 Sep 2025 06:25:25 +0000 /umbi/?post_type=news&p=103505 We are proud of Ts. Dr. Saiful Effendi Syafruddin‘s role as a resource person and speaker at the 3rd Youth Forum on Agricultural Biotechnology held ...

The post UMBI’s Researcher at the 3rd Youth Forum on Agricultural Biotechnology held in Dhaka, Bangladesh first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]>
We are proud of Ts. Dr. Saiful Effendi Syafruddin‘s role as a resource person and speaker at the 3rd Youth Forum on Agricultural Biotechnology held in Dhaka, Bangladesh from 13-15 September 2025. The event was co-organized by COMSTECH – OIC Standing Committee on Scientific and Technological Cooperation, Islamic Organization for Food Security (IOFS), and North South University (NSU), bringing together researchers from OIC member countries including Bangladesh, Pakistan, Turkey, Kazakhstan, Azerbaijan, and Malaysia.
Dr. Saiful delivered a talk on CRISPR/Cas9 technical challenges and the gene editing regulatory & biosafety landscape in Malaysia, participated in a Scientists-Students Engagement Session at NSU to share insights on cancer biology and kidney cancer research, and was also invited to speak at Jahangirnagar University on CRISPR/Cas9 technology and its applications in biomedical research.
What stood out was the vibrant research ecosystem and the remarkable quality of faculties and students across OIC members. This inspiring experience also provided the opportunity to proudly promote the cutting-edge research and state-of-the-art facilities at ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute (UMBI). ??
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SDG 17 | Keywords: Global partnership
SDG 4 | Keywords: Knowledge sharing
The post UMBI’s Researcher at the 3rd Youth Forum on Agricultural Biotechnology held in Dhaka, Bangladesh first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> Research Updates Series in Molecular Medicine No. 24/2025 /umbi/news/rus_no25_diabetes/ Fri, 12 Sep 2025 08:13:46 +0000 /umbi/?post_type=news&p=103514 UMBI Research Update Series in Molecular Medicine on 12 September 2025 featured two UMBI Research Fellows presenting on the topic of Diabetes. Dr. Siti Aishah ...

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UMBI Research Update Series in Molecular Medicine on 12 September 2025 featured two UMBI Research Fellows presenting on the topic of Diabetes.

Dr. Siti Aishah Sulaiman delivered a presentation on the latest updates in Diabetes, with emphasis on the classification of types and sub-types. There are subtypes within Type 2 diabetes (T2D), and the new classification of Malnutrition-related diabetes mellitus (MRDM) as Type 5 diabetes (T5D).Ìý T5D was officially recognised by the International Diabetes Federation (IDF) in April 2025. She also discussed ethnic-related differences across the five identified subtypes: Severe Auto Immune Diabetes (SAID), Severe Insulin-Deficient Diabetes (SIDD), Severe Insulin-Resistant Diabetes (SIRD), Mild Obesity-related Diabetes (MOD), and Mild Age-Related Diabetes (MARD), with Asians are more SIDD compared to Caucasians.

Dr. Noraidatulakma Abdullah presented initial findings from the PRIME Study on the diverse phenotypic faces of Type 2 Diabetes in Malaysia. The study identified three clusters—Low Risk, Moderate to Higher Risk, and High Risk at baseline—which can help predict patients at higher risk of developing complications upon diagnosis. These presentations underscored the importance of precision medicine approaches in understanding Diabetes and improving patient care in Malaysia and beyond.

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SDG 3 | SDG 4

Keywords: Diseases, Education

The post Research Updates Series in Molecular Medicine No. 24/2025 first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]> Research Updates Series in Molecular Medicine No. 21/2025 /umbi/news/rus-no-21-2025/ Fri, 15 Aug 2025 10:00:54 +0000 /umbi/?post_type=news&p=103462 We had two presentation during our weekly Research Update Series in Molecular Medicine earlier this morning. Dr. Nor Adzimah Johdi, UMBI Research Fellow shared the ...

The post Research Updates Series in Molecular Medicine No. 21/2025 first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]>

We had two presentation during our weekly Research Update Series in Molecular Medicine earlier this morning.

Dr. Nor Adzimah Johdi, UMBI Research Fellow shared the latest updates in tumor immunology, focusing on the diversity of CD8+ T Cells and the mechanisms of T cell dysfunction in cancer and viral infections. The updates shared were truly eye-opening, shedding light on the complexity of immune responses and their implications for immunotherapy strategies.


Mr. Jomel B. Vasquez, UMBI PhD student, presented his current progress on drug repositioning against MRSA. Currently still at an early stage of progress, his work explores the molecular interactions of candidate compounds. We wish him the best of luck in his experiments and look forward to more interesting updates in the future.

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SDG 3 | SDG 4

Keywords: Diseases, Education, Innovation

The post Research Updates Series in Molecular Medicine No. 21/2025 first appeared on ¼¯ÃÀÂ鶹 Medical Molecular Biology Institute.]]>