UMBI Research Spotlight No.2/2026
饾悇饾惐饾惄饾惀饾惃饾惈饾悽饾惂饾悹 饾悅饾悺饾悮饾惀饾惀饾悶饾惂饾悹饾悶饾惉 饾悮饾惂饾悵 饾悎饾惂饾惌饾悶饾悹饾惈饾悮饾惌饾悽饾惎饾悶 饾悞饾惃饾惀饾惍饾惌饾悽饾惃饾惂饾惉 饾悽饾惂 饾悞饾悽饾惂饾悹饾惀饾悶-饾悅饾悶饾惀饾惀 饾悎饾惁饾惁饾惍饾惂饾惃饾惀饾惃饾悹饾惒
UMBI is pleased to share a recent review article by our researchers, led by Dr. Nor Adzimah Johdi, published in 饾懓饾拵饾拵饾挅饾拸饾拹饾拲饾拹饾拡饾拪饾拕 饾懝饾拞饾挃饾拞饾拏饾挀饾拕饾拤, examining current challenges and emerging approaches in immune cell annotation within single-cell studies.
饾悞饾悽饾惂饾悹饾惀饾悶-饾悳饾悶饾惀饾惀 饾悜饾悕饾悁 饾惉饾悶饾惇饾惍饾悶饾惂饾悳饾悽饾惂饾悹 (饾惉饾悳饾悜饾悕饾悁-饾惉饾悶饾惇) has significantly advanced immunology research by enabling high-resolution profiling of individual immune cells. However, accurately identifying immune cell populations remains complex, particularly when transcriptomic signals do not always correspond directly with protein expression. This review discusses how these biological and technical challenges can influence 饾悵饾悮饾惌饾悮 饾悽饾惂饾惌饾悶饾惈饾惄饾惈饾悶饾惌饾悮饾惌饾悽饾惃饾惂 in areas such as cancer, infectious diseases, and autoimmune disorders.
The article provides an 饾惃饾惎饾悶饾惈饾惎饾悽饾悶饾惏 饾惃饾悷 饾悶饾惁饾悶饾惈饾悹饾悽饾惂饾悹 饾惁饾惍饾惀饾惌饾悽饾惁饾惃饾悵饾悮饾惀 饾惌饾悶饾悳饾悺饾惂饾惃饾惀饾惃饾悹饾悽饾悶饾惉, including CITE-seq and spatial transcriptomics, which combine transcriptomic, proteomic, and spatial information to support more reliable immune cell characterization. It also highlights 饾惈饾悶饾悳饾悶饾惂饾惌 饾悵饾悶饾惎饾悶饾惀饾惃饾惄饾惁饾悶饾惂饾惌饾惉 饾悽饾惂 饾悳饾惃饾惁饾惄饾惍饾惌饾悮饾惌饾悽饾惃饾惂饾悮饾惀 饾悮饾惂饾悵 饾悰饾悽饾惃饾悽饾惂饾悷饾惃饾惈饾惁饾悮饾惌饾悽饾悳饾惉 饾悷饾惈饾悮饾惁饾悶饾惏饾惃饾惈饾悿饾惉 designed to improve the integration and interpretation of multi-omics datasets.
Why these matters?
Improving the accuracy of immune cell annotation is increasingly important for advancing precision medicine and translational research. More robust analytical approaches may contribute to better understanding of disease mechanisms, improved therapeutic stratification, and the identification of potential treatment targets.
This publication also reflects UMBI鈥檚 continued efforts to contribute to the broader scientific community through interdisciplinary research spanning immunology, genomics, and computational biology.
We invite colleagues and collaborators to explore the full review:
George, S., Johdi, N.A. Immune cell annotation in the single-cell studies: technologies, challenges, and integrative solutions. 饾懓饾拵饾拵饾挅饾拸饾拹饾拲 饾懝饾拞饾挃 饾煏饾煉, 46 (2026)
As single-cell and multi-omics technologies continue to evolve, integrative approaches such as these may help strengthen future research in immunology and precision health.
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#Research #SingleCell #Immunology #Multiomics #PrecisionMedicine #BiomedicalResearch #Bioinformatics #UMBI #集美麻豆 #Innovation
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