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Sains Malaysiana 47(6)(2018): 1189–1197
http://dx.doi.org/10.17576/jsm-2018-4706-14
Influence
of Poly (Ethylene Glycol) on the Characteristics of γ
Radiation-Crosslinked Poly (Vinyl Pyrrolidone)-Low Molecular Weight
Chitosan Network Hydrogels (Kesan Poli(etilena
glikol) ke atas Ciri-ciri Jaringan Hidrogel Kitosan Berjisim Molekul
MAZNAH MAHMUD1,2*, RUSLI DAIK1 & ZAINAH ADAM 2
1School of Chemical Sciences and Food
Technology, Universiti Kebangsaan Malaysia
43600 ¼¯ÃÀÂ鶹 Bangi, Selangor Darul Ehsan, Malaysia
2Radiation Processing Technology
Division, Malaysian Nuclear Agency
43000 Kajang, Selangor Darul Ehsan, Malaysia
3Medical Technology Division, Malaysian
Nuclear Agency, 43000 Kajang, Selangor Darul Ehsan
Malaysia
Received: 9 June 2017/Accepted: 8 January
2018
ABSTRACT
PEG at compositions of 10, 15
and 20 g were added into the initial formulation of hydrogel L, which was
composed of 6 g low molecular weight chitosan (LMC)
and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were
moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were
characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces
almost 27% crosslinking density of the LMC-PVP hydrogel yet increased
hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in
phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively.
Also PEG enhanced the ability of LMC-PVP hydrogel
to retain its moisture from dehydration at body temperature. The morphological
study showed PEG developed thick pores wall and reduced the pores size
of the hydrogels’ network.
Keywords: Covalent-crosslink; plasticizer;
porosity; swelling-equilibrium; syneresis
ABSTRAK PEG
dengan komposisi yang pelbagai
iaitu 10, 15 dan 20 g telah ditambah ke dalam formulasi asal hidrogel
L yang telah disediakan melalui pengadunan 6 g kitosan berjisin
molekul rendah (LMC)
dengan 14 g poli (vinil pirolidon) dan 100 g asid laktik berkepekatan
2%. Semua adunan dimasukkan dalam acuan dan didedahkan kepada sinar
γ pada dos 7kGy. Hidrogel yang diperoleh
dibuat pencirian daripada aspek kandungan gel, sifat pembengkakan,
kesan sineresis, FTIR,
XRD
dan morfologi hidrogel menggunakan mikroskop imbasan
elektron (SEM).
Keputusan pencirian menunjukkan 10 g PEG telah mengurangkan ketumpatan
jaringan taut silangan hidrogel sebanyak 14% tetapi meningkatkan
keupayaan memegang air daripada 450% dan 480% kepada 750% dan 650%
masing-masing dalam larutan penimbal fosfat (PBS)
pada pH5.5 dan pH7.0. PEG juga meningkatkan keupayaan hidrogel
LMC-PVP untuk mengekalkan kelembapannya daripada terhidrat
pada suhu badan. Kajian morfologi juga menunjukkan PEG telah
membentuk satu jaringan hidrogel berliang lebih kecil dengan dinding
liang yang lebih tebal. Kata kunci: Keliangan; pembengkakan ekuilibrium; pemplastik; sineresis; taut silang kovalen
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*Corresponding author; email: maznah@nuclearmalaysia.gov.my
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